The I4SUD curriculum will be grounded in theoretical frameworks that are commonly used in entrepreneurial education, applied in our existing entrepreneurship programs at the Johns Hopkins Carey Business School, and complemented by concepts related to identity formation and community-building. The specific pedagogical structure of the I4SUD program will be grounded on two major themes: a cyclical framework of innovation management and a scientific method of execution. Successful entrepreneurship education is experience-based. Most programs around the world embrace this experiential model, and it is a prevalent theme in much of the research in the field. In addition to the enhanced learning that occurs when Innovators interact with faculty and mentors, to immediately apply what they learn, organizing their education around an actual project can lead to the commercialization of products or services that impact Substance Use Disorders.